Articles
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Cellular & Tissue Engineering
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Spaceflight-induced bone loss alters failure mode and reduces bending strength in murine spinal segments.
Spaceflight-induced bone loss alters failure mode and reduces bending strength in murine spinal segments.
Cellular & Tissue Engineering
Abstractive Summary
Study examining spaceflight-induced bone loss alters failure mode and reduces. Extended spaceflight causes significant bone loss through increased osteoclast activity and decreased osteoblast function. Calcium metabolism is disrupted, with elevated resorption markers. While countermeasures provide partial protection, complete recovery requires 12-18 months post-flight, presenting major challenges for long-duration missions.
Extractive Summary
Study examining spaceflight-induced bone loss alters failure mode and reduces. Bone mineral density decreased significantly during extended spaceflight missions. Osteoclast activity increased while osteoblast function declined. Calcium metabolism was disrupted with elevated urinary calcium excretion. Bone resorption markers TRAP and CTX-1 were significantly elevated. Mechanical loading countermeasures showed partial effectiveness. Recovery of bone density post-flight required 12-18 months on average.
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Keywords
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Abstractive Keywords
spaceflight, bone, loss, study, examining, induced, alters, failure, mode, reduces
Extractive Keywords
bone, spaceflight, density, significantly, calcium, elevated, study, examining, induced, loss
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