Articles
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Cellular & Tissue Engineering
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Spaceflight Modulates the Expression of Key Oxidative Stress and Cell Cycle Related Genes in Heart
Spaceflight Modulates the Expression of Key Oxidative Stress and Cell Cycle Related Genes in Heart
Cellular & Tissue Engineering
Abstractive Summary
Spaceflight induces oxidative stress and disrupts normal cell cycle regulation. This study examined gene expression changes in response to spaceflight exposure. Results showed significant alterations in antioxidant defense systems and cell cycle control mechanisms, highlighting potential health risks and the need for protective interventions during space missions.
Extractive Summary
Spaceflight exposure resulted in significant modulation of oxidative stress response genes and cell cycle regulators. Key antioxidant enzymes showed altered expression patterns during and after spaceflight. The study identified potential biomarkers for spaceflight-induced oxidative stress. Cell cycle checkpoint genes were downregulated, suggesting increased vulnerability to DNA damage. These molecular changes may contribute to long-term health risks associated with space travel.
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Keywords
spaceflight, modulates, expression, oxidative, stress, cell, cycle, related, genes, heart, spaceflight, oxidative, stress, genes, cell, cycle, exposure, resulted, significant, modulation, spaceflight, cell, cycle, induces, oxidative, stress, disrupts, normal, regulation, study
Abstractive Keywords
spaceflight, cell, cycle, induces, oxidative, stress, disrupts, normal, regulation, study
Extractive Keywords
spaceflight, oxidative, stress, genes, cell, cycle, exposure, resulted, significant, modulation
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