Articles
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Neurological & Sensory System Changes
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Understanding the Complexities and Changes of the Astronaut Microbiome for Successful Long-Duration Space Missions
Understanding the Complexities and Changes of the Astronaut Microbiome for Successful Long-Duration Space Missions
Neurological & Sensory System Changes
Abstractive Summary
Study examining simulated microgravity promotes horizontal gene transfer of antimicrobial. Spaceflight triggers widespread changes in gene expression affecting stress responses, DNA repair, and mitochondrial function. Epigenetic modifications occur, with some changes persisting long after return. Understanding these molecular adaptations is fundamental to developing effective countermeasures for long-duration missions.
Extractive Summary
Study examining simulated microgravity promotes horizontal gene transfer of antimicrobial. Genome-wide expression analysis revealed thousands of differentially expressed genes. Stress response pathways were universally upregulated. DNA repair genes showed increased expression. Mitochondrial genes were downregulated substantially. Epigenetic modifications included altered methylation patterns. Some changes persisted months after return to Earth. Cell cycle regulation genes were significantly affected.
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Keywords
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Abstractive Keywords
gene, changes, long, study, examining, simulated, microgravity, promotes, horizontal, transfer
Extractive Keywords
genes, expression, study, examining, simulated, microgravity, promotes, horizontal, gene, transfer
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