Articles
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Cellular & Tissue Engineering
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Validation of methods to assess the immunoglobulin gene repertoire in tissues obtained from mice on the International Space Station.
Validation of methods to assess the immunoglobulin gene repertoire in tissues obtained from mice on the International Space Station.
Cellular & Tissue Engineering
Abstractive Summary
Study examining validation of methods to assess the immunoglobulin gene. Spaceflight triggers widespread changes in gene expression affecting stress responses, DNA repair, and mitochondrial function. Epigenetic modifications occur, with some changes persisting long after return. Understanding these molecular adaptations is fundamental to developing effective countermeasures for long-duration missions.
Extractive Summary
Study examining validation of methods to assess the immunoglobulin gene. Genome-wide expression analysis revealed thousands of differentially expressed genes. Stress response pathways were universally upregulated. DNA repair genes showed increased expression. Mitochondrial genes were downregulated substantially. Epigenetic modifications included altered methylation patterns. Some changes persisted months after return to Earth. Cell cycle regulation genes were significantly affected.
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Keywords
validation, methods, assess, immunoglobulin, gene, repertoire, tissues, obtained, from, mice, genes, expression, study, examining, validation, methods, assess, immunoglobulin, gene, genome, gene, changes, long, study, examining, validation, methods, assess, immunoglobulin, spaceflight
Abstractive Keywords
gene, changes, long, study, examining, validation, methods, assess, immunoglobulin, spaceflight
Extractive Keywords
genes, expression, study, examining, validation, methods, assess, immunoglobulin, gene, genome
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