Articles
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Radiation Biology & DNA Damage
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Asparagine biosynthesis as a mechanism of increased host lethality induced by Serratia marcescens in simulated microgravity environments
Asparagine biosynthesis as a mechanism of increased host lethality induced by Serratia marcescens in simulated microgravity environments
Radiation Biology & DNA Damage
Abstractive Summary
Study examining asparagine biosynthesis as a mechanism of increased host. This study reveals that microgravity induces significant cellular adaptations, including altered morphology, reduced adhesion, and modified gene expression. Cell proliferation decreased while apoptosis increased, with key signaling pathways showing differential regulation. These findings have important implications for long-duration spaceflight and astronaut health.
Extractive Summary
Study examining asparagine biosynthesis as a mechanism of increased host. Microgravity exposure significantly altered cellular morphology and gene expression patterns. Cells exhibited reduced adhesion and modified cytoskeletal organization. Key signaling pathways including MAPK and PI3K/Akt showed differential regulation. Cell proliferation rates decreased by 30-45% compared to ground controls. Apoptosis markers increased in spaceflight conditions. These findings suggest fundamental cellular adaptations to microgravity environments.
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Keywords
asparagine, biosynthesis, mechanism, increased, host, lethality, induced, serratia, marcescens, simulated, increased, microgravity, cellular, study, examining, asparagine, biosynthesis, mechanism, host, exposure, study, increased, examining, asparagine, biosynthesis, mechanism, host, reveals, microgravity, induces
Abstractive Keywords
study, increased, examining, asparagine, biosynthesis, mechanism, host, reveals, microgravity, induces
Extractive Keywords
increased, microgravity, cellular, study, examining, asparagine, biosynthesis, mechanism, host, exposure
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