Effects of spaceflight aboard the International Space Station on mouse estrous cycle and ovarian gene expression
Radiation Biology & DNA Damage
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The cardiovascular system undergoes significant deconditioning in space, including reduced cardiac mass, blood volume, and increased arterial stiffness. These changes result in orthostatic intolerance upon return, affecting crew safety and performance during re-entry and landing.
Effects of spaceflight aboard the International Space Statioion. Cardiovascular deconditioning occurred during extended microgravity exposure. Cardiac mass decreased by 10-12%. Blood volume reduction was observed within the first week. Orthostatic intolerance developed in most crew members. Arterial stiffness increased during flight. These changes impacted physical capacity upon return to Earth.