Articles
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Radiation Biology & DNA Damage
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Chondrogenesis and mineralization during in vitro culture of human mesenchymal stem cells on three-dimensional woven scaffolds
Chondrogenesis and mineralization during in vitro culture of human mesenchymal stem cells on three-dimensional woven scaffolds
Radiation Biology & DNA Damage
Abstractive Summary
Study examining chondrogenesis and mineralization during in vitro culture of. Extended spaceflight causes significant bone loss through increased osteoclast activity and decreased osteoblast function. Calcium metabolism is disrupted, with elevated resorption markers. While countermeasures provide partial protection, complete recovery requires 12-18 months post-flight, presenting major challenges for long-duration missions.
Extractive Summary
Study examining chondrogenesis and mineralization during in vitro culture of. Bone mineral density decreased significantly during extended spaceflight missions. Osteoclast activity increased while osteoblast function declined. Calcium metabolism was disrupted with elevated urinary calcium excretion. Bone resorption markers TRAP and CTX-1 were significantly elevated. Mechanical loading countermeasures showed partial effectiveness. Recovery of bone density post-flight required 12-18 months on average.
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Keywords
chondrogenesis, mineralization, during, vitro, culture, human, mesenchymal, stem, cells, three, bone, during, density, significantly, calcium, elevated, study, examining, chondrogenesis, mineralization, study, examining, chondrogenesis, mineralization, during, vitro, culture, extended, spaceflight, causes
Abstractive Keywords
study, examining, chondrogenesis, mineralization, during, vitro, culture, extended, spaceflight, causes
Extractive Keywords
bone, during, density, significantly, calcium, elevated, study, examining, chondrogenesis, mineralization
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