Articles
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Radiation Biology & DNA Damage
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Chronic skeletal unloading of the rat femur: mechanisms and functional consequences of vascular remodeling.
Chronic skeletal unloading of the rat femur: mechanisms and functional consequences of vascular remodeling.
Radiation Biology & DNA Damage
Abstractive Summary
Study examining chronic skeletal unloading of the rat femur: mechanisms. Extended spaceflight causes significant bone loss through increased osteoclast activity and decreased osteoblast function. Calcium metabolism is disrupted, with elevated resorption markers. While countermeasures provide partial protection, complete recovery requires 12-18 months post-flight, presenting major challenges for long-duration missions.
Extractive Summary
Study examining chronic skeletal unloading of the rat femur: mechanisms. Bone mineral density decreased significantly during extended spaceflight missions. Osteoclast activity increased while osteoblast function declined. Calcium metabolism was disrupted with elevated urinary calcium excretion. Bone resorption markers TRAP and CTX-1 were significantly elevated. Mechanical loading countermeasures showed partial effectiveness. Recovery of bone density post-flight required 12-18 months on average.
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Keywords
chronic, skeletal, unloading, femur, mechanisms, functional, consequences, vascular, remodeling, bone, density, significantly, calcium, elevated, study, examining, chronic, skeletal, unloading, study, examining, chronic, skeletal, unloading, femur, mechanisms, extended, spaceflight, causes
Abstractive Keywords
study, examining, chronic, skeletal, unloading, femur, mechanisms, extended, spaceflight, causes
Extractive Keywords
bone, density, significantly, calcium, elevated, study, examining, chronic, skeletal, unloading
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