Articles
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Radiation Biology & DNA Damage
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Comprehensive multi-omics analysis reveals mitochondrial stress as a central biological hub for spaceflight impact
Comprehensive multi-omics analysis reveals mitochondrial stress as a central biological hub for spaceflight impact
Radiation Biology & DNA Damage
Abstractive Summary
This genomic analysis identified widespread gene expression changes during spaceflight, affecting stress responses and metabolism. Persistent epigenetic modifications suggest long-term effects that may impact astronaut health and require continued monitoring post-mission.
Extractive Summary
Gene expression profiling revealed over 1,000 differentially expressed genes in spaceflight conditions. Stress response pathways were upregulated while metabolic genes showed downregulation. Epigenetic modifications including DNA methylation changes were observed. These molecular alterations persisted for weeks after return to Earth.
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Keywords
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Abstractive Keywords
analysis, paper, comprehensive, multi, omics, reveals, mitochondrial, genomic, identified, widespread
Extractive Keywords
genes, paper, comprehensive, multi, omics, analysis, reveals, mitochondrial, gene, expression
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