Effects of Skeletal Unloading on the Vasomotor Properties of the Rat Femur Principal Nutrient Artery
Radiation Biology & DNA Damage
effects, skeletal, unloading, vasomotor, properties, femur, principal, nutrient, artery, bone, density, significantly, calcium, elevated, study, examining, effects, skeletal, unloading, study, examining, effects, skeletal, unloading, vasomotor, properties, extended, spaceflight, causes
effects, skeletal, unloading, vasomotor, properties, femur, principal, nutrient, artery
study, examining, effects, skeletal, unloading, vasomotor, properties, extended, spaceflight, causes
bone, density, significantly, calcium, elevated, study, examining, effects, skeletal, unloading
Study examining effects of skeletal unloading on the vasomotor properties. Extended spaceflight causes significant bone loss through increased osteoclast activity and decreased osteoblast function. Calcium metabolism is disrupted, with elevated resorption markers. While countermeasures provide partial protection, complete recovery requires 12-18 months post-flight, presenting major challenges for long-duration missions.
Study examining effects of skeletal unloading on the vasomotor properties. Bone mineral density decreased significantly during extended spaceflight missions. Osteoclast activity increased while osteoblast function declined. Calcium metabolism was disrupted with elevated urinary calcium excretion. Bone resorption markers TRAP and CTX-1 were significantly elevated. Mechanical loading countermeasures showed partial effectiveness. Recovery of bone density post-flight required 12-18 months on average.