Knowledge Network Embedding of Transcriptomic Data from Spaceflown Mice Uncovers Signs and Symptoms Associated with Terrestrial Diseases
Radiation Biology & DNA Damage
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This research examined muscle adaptation to microgravity, finding rapid atrophy particularly in slow-twitch fibers and lower limbs. Increased protein degradation combined with reduced synthesis drove muscle loss, though resistance exercise provided partial protection against these changes.
Skeletal muscle atrophy was evident within the first month of spaceflight. Type I slow-twitch muscle fibers showed preferential atrophy compared to Type II fibers. Protein degradation pathways were activated while synthesis was suppressed. Lower limb muscles exhibited greater atrophy than upper limb muscles. Resistance exercise partially mitigated muscle loss.