Articles
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Radiation Biology & DNA Damage
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Modeled microgravity alters apoptotic gene expression and caspase activity in the squid-vibrio symbiosis
Modeled microgravity alters apoptotic gene expression and caspase activity in the squid-vibrio symbiosis
Radiation Biology & DNA Damage
Abstractive Summary
Study examining modeled microgravity alters apoptotic gene expression and caspase. Spaceflight triggers widespread changes in gene expression affecting stress responses, DNA repair, and mitochondrial function. Epigenetic modifications occur, with some changes persisting long after return. Understanding these molecular adaptations is fundamental to developing effective countermeasures for long-duration missions.
Extractive Summary
Study examining modeled microgravity alters apoptotic gene expression and caspase. Genome-wide expression analysis revealed thousands of differentially expressed genes. Stress response pathways were universally upregulated. DNA repair genes showed increased expression. Mitochondrial genes were downregulated substantially. Epigenetic modifications included altered methylation patterns. Some changes persisted months after return to Earth. Cell cycle regulation genes were significantly affected.
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Keywords
modeled, microgravity, alters, apoptotic, gene, expression, caspase, activity, squid, vibrio, genes, expression, study, examining, modeled, microgravity, alters, apoptotic, gene, caspase, gene, expression, changes, long, study, examining, modeled, microgravity, alters, apoptotic
Abstractive Keywords
gene, expression, changes, long, study, examining, modeled, microgravity, alters, apoptotic
Extractive Keywords
genes, expression, study, examining, modeled, microgravity, alters, apoptotic, gene, caspase
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