Articles
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Radiation Biology & DNA Damage
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Spaceflight-induced alterations in cerebral artery vasoconstrictor, mechanical, and structural properties: Implications for elevated cerebral perfusion and intracranial pressure
Spaceflight-induced alterations in cerebral artery vasoconstrictor, mechanical, and structural properties: Implications for elevated cerebral perfusion and intracranial pressure
Radiation Biology & DNA Damage
Abstractive Summary
Study examining spaceflight-induced alterations in cerebral artery vasoconstrictor, mechanical, and. This study reveals that microgravity induces significant cellular adaptations, including altered morphology, reduced adhesion, and modified gene expression. Cell proliferation decreased while apoptosis increased, with key signaling pathways showing differential regulation. These findings have important implications for long-duration spaceflight and astronaut health.
Extractive Summary
Study examining spaceflight-induced alterations in cerebral artery vasoconstrictor, mechanical, and. Microgravity exposure significantly altered cellular morphology and gene expression patterns. Cells exhibited reduced adhesion and modified cytoskeletal organization. Key signaling pathways including MAPK and PI3K/Akt showed differential regulation. Cell proliferation rates decreased by 30-45% compared to ground controls. Apoptosis markers increased in spaceflight conditions. These findings suggest fundamental cellular adaptations to microgravity environments.
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Keywords
cerebral, spaceflight, induced, alterations, artery, vasoconstrictor, mechanical, structural, properties, implications, spaceflight, microgravity, cellular, study, examining, induced, alterations, cerebral, artery, vasoconstrictor, study, spaceflight, examining, induced, alterations, cerebral, artery, vasoconstrictor, mechanical, reveals
Abstractive Keywords
study, spaceflight, examining, induced, alterations, cerebral, artery, vasoconstrictor, mechanical, reveals
Extractive Keywords
spaceflight, microgravity, cellular, study, examining, induced, alterations, cerebral, artery, vasoconstrictor
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