Mice in Bion-M 1 space mission: training and selection

Microgravity induces pelvic bone loss through osteoclastic activity, osteocytic osteolysis, and osteoblastic cell cycle inhibition by CDKN1a/p21

Stem Cell Health and Tissue Regeneration in Microgravity

Microgravity Reduces the Differentiation and Regenerative Potential of Embryonic Stem Cells

Microgravity validation of a novel system for RNA isolation and multiplex quantitative real time PCR analysis of gene expression on the International Space Station

Spaceflight Modulates the Expression of Key Oxidative Stress and Cell Cycle Related Genes in Heart

Dose- and Ion-Dependent Effects in the Oxidative Stress Response to Space-Like Radiation Exposure in the Skeletal System

From the bench to exploration medicine: NASA life sciences translational research for human exploration and habitation missions.

High-precision method for cyclic loading of small-animal vertebrae to assess bone quality.

Effects of ex vivo ionizing radiation on collagen structure and whole-bone mechanical properties of mouse vertebrae.

Absence of gamma-sarcoglycan alters the response of p70S6 kinase to mechanical perturbation in murine skeletal muscle

AtRabD2b and AtRabD2c have overlapping functions in pollen development and pollen tube growth.

TNO1 is involved in salt tolerance and vacuolar trafficking in Arabidopsis.

Functional redundancy between trans-Golgi network SNARE family members in Arabidopsis thaliana.

Root growth movements: Waving and skewing.

Gravitropism and lateral root emergence are dependent on the trans-Golgi network protein TNO1

TNO1, a TGN-localized SNARE-interacting protein, modulates root skewing in Arabidopsis thaliana.

The Drosophila SUN protein Spag4 cooperates with the coiled-coil protein Yuri Gagarin to maintain association of the basal body and spermatid nucleus.

Toll mediated infection response is altered by gravity and spaceflight in Drosophila

Multi-omics analysis of multiple missions to space reveal a theme of lipid dysregulation in mouse liver

GeneLab database analyses suggest long-term impact of space radiation on the cardiovascular system by the activation of FYN through reactive oxygen species.

FAIRness and usability for open-access omics data systems.

NASA GeneLab platform utilized for biological response to space radiation in animal models

Circulating miRNA spaceflight signature reveals targets for countermeasure development

Machine learning algorithm to characterize antimicrobial resistance associated with the International Space Station surface microbiome

Extraterrestrial Gynecology: Could Spaceflight Increase the Risk of Developing Cancer in Female Astronauts? An Updated Review

Muscle atrophy phenotype gene expression during spaceflight is linked to a metabolic crosstalk in both the liver and the muscle in mice.

Chromosomal positioning and epigenetic architecture influence DNA methylation patterns triggered by galactic cosmic radiation

A comprehensive SARS-CoV-2 and COVID-19 review, Part 2: Host extracellular to systemic effects of SARS-CoV-2 infection

Aging and putative frailty biomarkers are altered by spaceflight

Space radiation damage rescued by inhibition of key spaceflight associated miRNAs

Ethical considerations for the age of non-governmental space exploration

Innate immune responses of Drosophila melanogaster are altered by spaceflight.

Prolonged Exposure to Microgravity Reduces Cardiac Contractility and Initiates Remodeling in Drosophila

Regulation of plant gravity sensing and signaling by the actin cytoskeleton.

HLB1 Is a Tetratricopeptide Repeat Domain-Containing Protein That Operates at the Intersection of the Exocytic and Endocytic Pathways at the TGN/EE in Arabidopsis

ERULUS is a plasma membrane-localized receptor-like kinase that specifies root hair growth by maintaining tip-focused cytoplasmic calcium oscillations.

Brassinosteroids inhibit autotropic root straightening by modifying filamentous-actin organization and dynamics.

Cell type-specific imaging of calcium signaling in Arabidopsis thaliana seedling roots using GCaMP3.

Spatial and temporal localization of SPIRRIG and WAVE/SCAR reveal roles for these proteins in actin-mediated root hair development.

Microgravity Stress: Bone and Connective Tissue

S. aureus MscL is a pentamer in vivo but of variable stoichiometries in vitro: implications for detergent-solubilized membrane proteins

Manipulating the permeation of charged compounds through the MscL nanovalve.

The oligomeric state of the truncated mechanosensitive channel of large conductance shows no variance in vivo.

Three routes to modulate the pore size of the MscL channel/nanovalve

The dynamics of protein-protein interactions between domains of MscL at the cytoplasmic-lipid interface

The MscS and MscL families of mechanosensitive channels act as microbial emergency release valves

Chimeras reveal a single lipid-interface residue that controls MscL channel kinetics as well as mechanosensitivity

Evidence for extensive horizontal gene transfer from the draft genome of a tardigrade

Reply to Bemm et al. and Arakawa: Identifying foreign genes in independent Hypsibius dujardini genome assemblies

Tardigrades Use Intrinsically Disordered Proteins to Survive Desiccation.

Desiccation of Hypsibius exemplaris

The biology of tardigrade disordered proteins in extreme stress tolerance.

Production of reactive oxygen species and involvement of bioprotectants during anhydrobiosis in the tardigrade Paramacrobiotus spatialis

Partial weight suspension: A novel murine model for investigating adaptation to reduced musculoskeletal loading.

Partial reductions in mechanical loading yield proportional changes in bone density, bone architecture, and muscle mass

Spaceflight and hind limb unloading induce similar changes in electrical impedance characteristics of mouse gastrocnemius muscle

Spaceflight Activates Lipotoxic Pathways in Mouse Liver

Treatment with a soluble bone morphogenetic protein type 1A receptor (BMPR1A) fusion protein increases bone mass and bone formation in mice subjected to hindlimb unloading.

RNAseq and RNA molecular barcoding reveal differential gene expression in cortical bone following hindlimb unloading in female mice

Proteomic and phosphoproteomic characterization of cardiovascular tissues after long term exposure to simulated space radiation

Adaptive Changes in the Vestibular System of Land Snail to a 30-Day Spaceflight and Readaptation on Return to Earth

Morphology of the Utricular Otolith Organ in the Toadfish, Opsanus tau

Influence of Magnitude and Duration of Altered Gravity and Readaptation to 1g on the Structure and Function of the Utricle in Toadfish, Opsanus tau.

Organization of the ER-Golgi interface for membrane traffic control.

IRE1: ER stress sensor and cell fate executor.

Inter-regulation of the unfolded protein response and auxin signaling.

Endoplasmic reticulum-shape and function in stress translation

Galactose-depleted xycoglucan is dysfunctional and leads to dwarfism in Arabidopsis

Unfolded protein response in plants: one master, many questions.

Vesicles versus Tubes: Is Endoplasmic Reticulum-Golgi Transport in Plants Fundamentally Different from Other Eukaryotes?

Pectin methylesterification impacts the relationship between photosynthesis and plant growth.

Reduced Chloroplast Coverage genes from Arabidopsis thaliana help to establish the size of the chloroplast compartment

Maintaining the factory: The roles of the unfolded protein response in cellular homeostasis in plants.

NADPH oxidase activity is required for ER stress survival in plants.

Relevance of the Unfolded Protein Response to Spaceflight-Induced Transcriptional Reprogramming in Arabidopsis

Reanalysis of the Mars500 experiment reveals common gut microbiome alterations in astronauts induced by long-duration confinement

High atomic weight, high-energy radiation (HZE) induces transcriptional responses shared with conventional stresses in addition to a core "DSB" response specific to clastogenic treatments

Genomic stability in response to high versus low linear energy transfer radiation in Arabidopsis thaliana

Acceleration profiles and processing methods for parabolic flight.

Cytoskeleton structure and total methylation of mouse cardiac and lung tissue during space flight.

Toward countering muscle and bone loss with spaceflight: GSK3 as a potential target

Spaceflight increases sarcoplasmic reticulum Ca2+ leak and this cannot be counteracted with BuOE treatment

Cardiovascular progenitor cells cultured aboard the International Space Station exhibit altered developmental and functional properties

Inter-agency perspective: Translating advances in biomarker discovery and medical countermeasures development between terrestrial and space radiation environments

Genomic and functional characterization of Enterococcus faecalis isolates recovered from the International Space Station and their potential for pathogenicity

Evaluation of in vitro macrophage differentiation during space flight.

Identification of critical host mitochondrion-associated genes during Ehrlichia chaffeensis infections

Ehrlichia chaffeensis replication sites in adult Drosophila melanogaster.

Development and characterization of two porcine monocyte-derived macrophage cell lines.

Understanding macrophage differentiation during space flight: The importance of ground-based experiments before space flight

Bone marrow leptin signaling mediates obesity-associated adipose tissue inflammation in male mice.

Establishment and characterization of DB-1: a leptin receptor-deficient murine macrophage cell line

Validation of methods to assess the immunoglobulin gene repertoire in tissues obtained from mice on the International Space Station.

Characterization of the naive murine antibody repertoire using unamplified high-throughput sequencing

Effects of spaceflight on the immunoglobulin repertoire of unimmunized C57BL/6 mice

A comparison of unamplified and massively multiplexed PCR amplification for murine antibody repertoire sequencing.

Effects of skeletal unloading on the antibody repertoire of tetanus toxoid and/or CpG treated C57BL/6J mice.

Effects of skeletal unloading on the bone marrow antibody repertoire of tetanus toxoid and/or CpG treated C57BL/6J mice.

An Analysis of the Effects of Spaceflight and Vaccination on Antibody Repertoire Diversity

Effects of spaceflight aboard the International Space Station on mouse estrous cycle and ovarian gene expression

Effect of spaceflight on Pseudomonas aeruginosa final cell density is modulated by nutrient and oxygen availability.

Spaceflight promotes biofilm formation by Pseudomonas aeruginosa.

GeneLab: Omics database for spaceflight experiments

NASA GeneLab: Interfaces for the exploration of space omics data

Comprehensive multi-omics analysis reveals mitochondrial stress as a central biological hub for spaceflight impact

A New Era for Space Life Science: International Standards for Space Omics Processing

Knowledge Network Embedding of Transcriptomic Data from Spaceflown Mice Uncovers Signs and Symptoms Associated with Terrestrial Diseases

NASA GeneLab RNA-Seq Consensus Pipeline: Standardized Processing of Short-Read RNA-Seq Data

Spatially resolved multiomics on the neuronal effects induced by spaceflight in mice

Biological horizons: pioneering open science in the cosmos

NASA GeneLab derived microarray studies of Mus musculus and Homo sapiens organisms in altered gravitational conditions.

Celebrating 30 years of access to NASA space life sciences data

Dichotomous effects on lymphatic transport with loss of caveolae in mice.

Fungal diversity differences in the indoor dust microbiome from built environments on Earth and in space.

Aging and estrogen status: A possible endothelium-dependent vascular coupling mechanism in bone remodeling.

Chronic skeletal unloading of the rat femur: mechanisms and functional consequences of vascular remodeling.

Differential effects of aging and exercise on intra-abdominal adipose arteriolar function and blood flow regulation.

Effects of spaceflight and ground recovery on mesenteric artery and vein constrictor properties in mice.

Spaceflight-induced alterations in cerebral artery vasoconstrictor, mechanical, and structural properties: Implications for elevated cerebral perfusion and intracranial pressure

Exercise training augments regional bone and marrow blood flow during exercise.

Effects of Skeletal Unloading on the Vasomotor Properties of the Rat Femur Principal Nutrient Artery

Type 2 diabetes alters bone and marrow blood flow and vascular control mechanisms in the ZDF rat.

Spaceflight on the Bion-M1 biosatellite alters cerebral artery vasomotor and mechanical properties in mice

Apollo Lunar Astronauts Show Higher Cardiovascular Disease Mortality: Possible Deep Space Radiation Effects on the Vascular Endothelium

Effects of age and exercise training on coronary microvascular smooth muscle phenotype and function

Impact of Spaceflight and Artificial Gravity on the Mouse Retina: Biochemical and Proteomic Analysis.

Simulated microgravity induces regionally distinct neurovascular and structural remodeling of skeletal muscle and cutaneous arteries in the rat

Spaceflight decelerates the epigenetic clock orchestrated with a global alteration in DNA methylome and transcriptome in the mouse retina

Development of otolith receptors in Japanese quail.

Spatial and temporal characteristics of vestibular convergence

Bone remodeling is regulated by inner ear vestibular signals

Simulated Microgravity Enhances Oligodendrocyte Mitochondrial Function and Lipid Metabolism

Human Neural Stem Cells Flown into Space Proliferate and Generate Young Neurons

Delayed Maturation of Oligodendrocyte Progenitors by Microgravity: Implications for Multiple Sclerosis and Space Flight

Space Microgravity Alters Neural Stem Cell Division: Implications for Brain Cancer Research on Earth and in Space

Oligodendrocyte Progenitors Display Enhanced Proliferation and Autophagy after Space Flight

Metabolomics profile of the secretome of space-flown oligodendrocytes.

Metabolomic profiling of the secretome from human neural stem cells flown into space.

Strategies, research priorities, and challenges for the exploration of space beyond low-Earth orbit

Spaceflight Induces Specific Alterations in the Proteomes of Arabidopsis

The effect of spaceflight on the gravity-sensing auxin gradient of roots: GFP reporter gene microscopy on orbit.

Skewing in Arabidopsis roots involves disparate environmental signaling pathways.

Data for characterization of SALK_084889, a T-DNA insertion line of Arabidopsis thaliana

Genetic dissection of the Arabidopsis spaceflight transcriptome: Are some responses dispensable for the physiological adaptation of plants to spaceflight?

Phenotypic characterization of an Arabidopsis T- DNA insertion line SALK_063500

Utilization of single‚Äêimage normalized difference vegetation index (SI‚ÄêNDVI) for early plant stress detection

Comparing RNA-Seq and microarray gene expression data in two zones of the Arabidopsis root apex relevant to spaceflight.

Spaceflight-induced alternative splicing during seedling development in Arabidopsis thaliana.

The Plant Health Monitoring System of the EDEN ISS Space Greenhouse in Antarctica during the 2018 experiment phase

Root skewing-associated genes impact the spaceflight response of Arabidopsis thaliana.

Articular cartilage and sternal fibrocartilage respond differently to extended microgravity.

Host-microbe interactions in microgravity: assessment and implications.

Environmental cues and symbiont microbe-associated molecular patterns function in concert to drive the daily remodelling of the crypt-cell brush border of the Euprymna scolopes light organ

Symbiotic organs shaped by distinct modes of genome evolution in cephalopods.

Modeled microgravity alters lipopolysaccharide and outer membrane vesicle production of the beneficial symbiont Vibrio fischeri

Emergence of novel cephalopod gene regulation and expression through large-scale genome reorganization

Modeled microgravity alters apoptotic gene expression and caspase activity in the squid-vibrio symbiosis

In vitro generation of mechanically functional cartilage grafts based on adult human stem cells and 3D-woven poly(epsilon-caprolactone) scaffolds

Chondrogenesis and mineralization during in vitro culture of human mesenchymal stem cells on three-dimensional woven scaffolds

Microbiome metadata standards: Report of the National Microbiome Data Collaborative's workshop and follow-on activities.

Spaceflight alters host-gut microbiota interactions

Asparagine biosynthesis as a mechanism of increased host lethality induced by Serratia marcescens in simulated microgravity environments

Comparative genomic analysis of Cohnella hashimotonis sp. nov. isolated from the International Space Station.

Biocontrol in built environments to reduce pathogen exposure and infection risk.

Extracellular nucleotides elicit cytosolic free calcium oscillations in Arabidopsis.

Calcium, mechanical signaling, and tip growth

Gravitropism and mechanical signaling in plants.

Salt stress-induced Ca2+ waves are associated with rapid, long-distance root-to-shoot signaling in plants.

Gravitropic signaling in plants

Wortmannin-induced vacuole fusion enhances amyloplast dynamics in Arabidopsis zigzag1 hypocotyls.

A ROS-assisted calcium wave dependent on AtRBOHD and TPC1 propagates the systemic response to salt stress in Arabidopsis roots

ROS, calcium and electric signals: Key mediators of rapid systemic signaling in plants

Real-time In Vivo Recording of Arabidopsis Calcium Signals During Insect Feeding Using a Fluorescent Biosensor

Orchestrating rapid long-distance signaling in plants with Ca2+ , ROS, and electrical signals

Glutamate triggers long-distance, calcium-based plant defense signaling.

Test of Arabidopsis Space Transcriptome: A discovery environment to explore multiple plant biology spaceflight experiments.

Tonoplast-localized Ca2+ pumps regulate Ca2+ signals during pattern-triggered immunity in Arabidopsis thaliana.

The fast and the furious: Rapid long-range signaling in plants.

Rad-Bio-App: A discovery environment for biologists to explore spaceflight-related radiation exposures

The vacuolar H+/Ca transporter CAX1 participates in submergence and anoxia stress responses.

Meta-analysis of the space flight and microgravity response of the Arabidopsis plant transcriptome

Low-dose, ionizing radiation and age-related changes in skeletal microarchitecture

Ionizing Radiation Stimulates Expression of Pro-Osteoclastogenic Genes in Marrow and Skeletal Tissue

Preservation of Multiple Mammalian Tissues to Maximize Science Return from Ground Based and Spaceflight Experiments

Hindlimb Unloading: Rodent Analog for Microgravity

Redox Signaling and Its Impact on Skeletal and Vascular Responses to Spaceflight

Influence of social isolation during prolonged simulated weightlessness by hindlimb unloading

Validation of a new Rodent experimental System to investigate consequences of Long Duration Space Habitation

Skeletal tissue regulation by catalase over-expression in mitochondria

Overexpression of catalase in mitochondria mitigates changes in hippocampal cytokine expression following simulated microgravity and isolation.

An extensive allelic series of Drosophila kae1 mutants reveals diverse and tissue-specific requirements for t6A biogenesis

Novel Organelles with Elements of Bacterial and Eukaryotic Secretion Systems Weaponize Parasites of Drosophila

A combined computational strategy of sequence and structural analysis predicts the existence of a functional eicosanoid pathway in Drosophila melanogaster.

Immune suppressive extracellular vesicle proteins of Leptopilina heterotoma are encoded in the wasp genome.

Spaceflight and simulated microgravity conditions increase virulence of Serratia marcescens in the Drosophila melanogaster infection model.

A parasitoid wasp of Drosophila employs preemptive and reactive strategies to deplete its host's blood cells

In Silico Analysis of a Drosophila Parasitoid Venom Peptide Reveals Prevalence of the Cation–Polar–Cation Clip Motif in Knottin Proteins

Drosophila parasitoids go to space: Unexpected effects of spaceflight on hosts and their parasitoids

Simultaneous exposure of cultured human lymphoblastic cells to simulated microgravity and radiation increases chromosome aberrations

Genes required for survival in microgravity revealed by genome-wide yeast deletion collections cultured during spaceflight.

Physical Forces Modulate Oxidative Status and Stress Defense Meditated Metabolic Adaptation of Yeast Colonies: Spaceflight and Microgravity Simulations

Effects of space flight on mouse liver versus kidney: Gene pathway analyses.

Yeast in Space

Endocrine Effects of Space Flight

Role of shear stress on renal proximal tubular cells for nephrotoxicity assays

Bone hemodynamic responses to changes in external pressure.

Back pain in space and post-flight spine injury: Mechanisms and countermeasure development

Fifteen days of microgravity causes growth in calvaria of mice

Altered disc compression in children with idiopathic low back pain: an upright magnetic resonance imaging backpack study

Spaceflight-induced bone loss alters failure mode and reduces bending strength in murine spinal segments.

Spaceflight-associated vascular remodeling and gene expression in mouse calvaria.

Exposure of Mycobacterium marinum to low-shear modeled microgravity: Effect on growth, the transcriptome and survival under stress.

Effects of mechanostimulation on gravitropism and signal persistence in flax roots.

Oxygen dependency of germinating Brassica seeds.

Desiccation mitigates heat stress in the resurrection fern, Pleopeltis polypodioides

Transcription profile of auxin related genes during positively gravitropic hypocotyl curvature of Brassica rapa.

High-gradient magnetic fields and starch metabolism: Results from a space experiment.

Lipid rafts and plant gravisensitivity.

Expression and characterization of the bacterial mechanosensitive channel MscS in Xenopus laevis oocytes

United in Diversity: Mechanosensitive Ion Channels in Plants

Expressing and Characterizing Mechanosensitive Channels in Xenopus Oocytes

The ongoing search for the molecular basis of plant osmosensing

Plastid osmotic stress influences cell differentiation at the plant shoot apex.

Spaceflight-induced synaptic modifications within hair cells of the mammalian utricle.

Effects of angular frequency during clinorotation on mesenchymal stem cell morphology and migration

The role of FGF-2 and BMP-2 in regulation of gene induction, cell proliferation and mineralization.

Nutritional supplements, COX-2 and IGF-1 expression in men on active surveillance for prostate cancer.

To Infinity and Beyond! Human spaceflight and life science.

Hyperoxia inhibits T cell activation in mice

Effects of gravitational mechanical unloading in endothelial cells: association between caveolins, inflammation and adhesion molecules

n-3 Polyunsaturated fatty acids supplementation in peripheral artery disease: the OMEGA-PAD trial

Molecular mechanisms underlying the enhanced functions of three-dimensional hepatocyte aggregates

Spaceflight alters expression of microRNA during T-cell activation

Spaceflight impairs antigen-specific tolerance induction in vivo and increases inflammatory cytokines.

From cellular mechanotransduction to biologically inspired engineering: 2009 Pritzker Award Lecture, BMES Annual Meeting October 10, 2009.

Crewmember microbiome may influence microbial composition of ISS habitable surfaces

Sierra Nevada sweep: Metagenomic measurements of bioaerosols vertically distributed across the troposphere.

Draft Genome Sequences of Fungi Isolated from the International Space Station during the Microbial Tracking-2 Experiment

Microbial tracking-2, a metagenomics analysis of bacteria and fungi onboard the International Space Station.

Detection of Target Genes for Drug Repurposing to Treat Skeletal Muscle Atrophy in Mice Flown in Spaceflight

Release of CD36-associated cell-free mitochondrial DNA and RNA as a hallmark of space environment response

Increasing the number of unloading/reambulation cycles does not adversely impac body composition and lumbar bone mineral density but reduces tissue sensitivity

Bone shaft bending strength index is unaffected by exercise and unloading in mice

Focal enhancement of the skeleton to exercise correlates to mesenchymal stem cell responsivity rather than peak external forces.

Cytoskeletal configuration modulates mechanically induced changes in mesenchymal stem cell osteogenesis, morphology, and stiffness.

Genetic and tissue level muscle-bone interactions during unloading and reambulation.

Osteocyte apoptosis caused by hindlimb unloading is required to trigger osteocyte RANKL production and subsequent resorption of cortical and trabecular bone in mice femurs.

Differential Single Cell Responses of Embryonic Stem Cells Versus Embryoid Bodies to Gravity Mechanostimulation

Macrophages inhibit Aspergillus fumigatus germination and neutrophil-mediated fungal killing.

Contributions of spore secondary metabolites to UV-C protection and virulence vary in different Aspergillus fumigatus strains

Regulation of hemocytes in Drosophila requires dappled cytochrome b5.

A novel phototropic response to red light is revealed in microgravity.

Plant cell proliferation and growth are altered by microgravity conditions in spaceflight.

Phototropism of Arabidopsis thaliana in microgravity and fractional gravity on the International Space Station.

Light and gravity signals synergize in modulating plant development

A novel blue-light phototropic response is revealed in roots of Arabidopsis thaliana in microgravity.

RNAseq analysis of the response of Arabidopsis thaliana to fractional gravity under blue-light stimulation during spaceflight

Comparison of Microgravity Analogs to Spaceflight in Studies of Plant Growth and Development

The importance of Earth reference controls in spaceflight-omics research: Characterization of nucleolin mutants from the Seedling Growth experiments

Conducting plant experiments in space and on the Moon

Red light enhances plant adaptation to spaceflight and Mars g-levels.

EUK-134 ameliorates nNOSµ translocation and skeletal muscle fiber atrophy during short-term mechanical unloading.

MnSOD Overexpression Reduces Fibrosis and Pro-Apoptotic Signaling in the Aging Mouse Heart

Lifelong wheel running exercise and mild caloric restriction attenuate nuclear EndoG in the aging plantaris muscle.

Age-related alterations in the sarcolemmal environment are attenuated by lifelong caloric restriction and voluntary exercise.

The impact of SRT2104 on skeletal muscle mitochondrial function, redox biology, and loss of muscle mass in hindlimb unloaded rats.

Bioreactor development for skeletal muscle hypertrophy and atrophy by manipulating uniaxial cyclic strain: Proof of concept.

Genomic and phenotypic characterization of Burkholderia isolates from the potable water system of the International Space Station

CAMDLES: CFD-DEM Simulation of Microbial Communities in Spaceflight and Artificial Microgravity

Hardware validation of the Advanced Plant Habitat on ISS: Canopy photosynthesis in reduced gravity.

Trimeric structure of (+)-pinoresinol-forming dirigent protein at 1.95 A resolution with three isolated active sites.

Reduced Arogenate Dehydratase Expression: Ramifications for Photosynthesis and Metabolism

New insights into lignification via network and multi-omics analyses of arogenate dehydratase knock-out mutants in Arabidopsis thaliana

Functional consequences of radiation-induced oxidative stress in cultured neural stem cells and the brain exposed to charged particle irradiation

Exploration of space to achieve scientific breakthroughs

Network Analysis of Gene Transcriptions of Arabidopsis thaliana in Spaceflight Microgravity.

Detection of Genes in Arabidopsis thaliana L. Responding to DNA Damage from Radiation and Other Stressors in Spaceflight

The Effect of spaceflight on mouse olfactory bulb volume, neurogenesis, and cell death indicates the protective effect of novel environment.

Effects of low-dose rate γ-irradiation combined with simulated microgravity on markers of oxidative stress, DNA methylation potential, and remodeling in the mouse heart

Characterization of mouse ocular response to a 35-day spaceflight mission: Evidence of blood-retinal barrier disruption and ocular adaptations.

Mice Exposed to Combined Chronic Low-Dose Irradiation and Modeled Microgravity Develop Long-Term Neurological Sequelae.

Spaceflight influences gene expression, photoreceptor integrity, and oxidative stress-related damage in the murine retina.

Evaluating ocular response in the retina and optic nerve head after single and fractionated high-energy protons

Characterization of gene expression profiles in the mouse brain after 35 days of spaceflight mission.

A multi-omics longitudinal study of the murine retinal response to chronic low-dose irradiation and simulated microgravity.

Evidence of spaceflight-induced adverse effects on photoreceptors and retinal function in the mouse eye.

Effects of spaceflight on the brain

Routine omics collection is a golden opportunity for European human research in space and analog environments.

Spatial omics technologies at multimodal and single cell/subcellular level.

Genomic characterization and radiation tolerance of Naganishia kalamii sp. nov. and Cystobasidium onofrii sp. nov. from Mars 2020 mission assembly facilities.

Genome and clonal hematopoiesis stability contrasts with immune, cfDNA, mitochondrial, and telomere length changes during short duration spaceflight

Inspiration4 data access through the NASA Open Science Data Repository

Molecular and physiologic changes in the SpaceX Inspiration4 civilian crew

Telomeric RNA (TERRA) increases in response to spaceflight and high-altitude climbing

Spatial multi-omics of human skin reveals KRAS and inflammatory responses to spaceflight

Longitudinal multi-omics analysis of host microbiome architecture and immune responses during short-term spaceflight

Spatiotemporal expression and control of haemoglobin in space

Single-cell multi-ome and immune profiles of the Inspiration4 crew reveal conserved, cell-type, and sex-specific responses to spaceflight

Single-cell analysis identifies conserved features of immune dysfunction in simulated microgravity and spaceflight

The Space Omics and Medical Atlas (SOMA) and international astronaut biobank

Secretome profiling reveals acute changes in oxidative stress, brain homeostasis, and coagulation following short-duration spaceflight

Astronaut omics and the impact of space on the human body at scale

Transcriptomics analysis reveals molecular alterations underpinning spaceflight dermatology.

Cosmic kidney disease: an integrated pan-omic, physiological and morphological study into spaceflight-induced renal dysfunction

Spaceflight induces changes in gene expression profiles linked to insulin and estrogen

Protective alleles and precision healthcare in crewed spaceflight

To boldly go where no microRNAs have gone before: Spaceflight impact on risk for small-for-gestational-age infants

Growth chambers on the International Space Station for large plants

Microbiological and nutritional analysis of lettuce crops grown on the International Space Station

Natural variation in the expression of ORGANIC CATION TRANSPORTER 1 affects root length responses to cadaverine in Arabidopsis.

Auxin: Shape matters.

Gravity signaling in flowering plant roots

Cadaverine regulates biotin synthesis to modulate primary root growth in Arabidopsis

Low-speed clinorotation of Brachypodium distachyon and Arabidopsis thaliana seedlings triggers root tip curvatures that are reminiscent of gravitropism.

New device for high-throughput viability screening of flow biofilms

Sigma S-dependent antioxidant defense protects stationary-phase Escherichia coli against the bactericidal antibiotic gentamicin

Plasma membrane disruption (PMD) formation and repair in mechanosensitive tissues

Microgravity alters the expression of salivary proteins

Salivary Gland Protein Expression after Bion-M1 and Space Shuttle STS-135 Missions

Response of the mouse sublingual gland to spaceflight.

Effects of spaceflight on the mouse submandibular gland

Reactivation of Latent Epstein-Barr Virus: A Comparison after Exposure to Gamma, Proton, Carbon, and Iron Radiation

The influence of spaceflight on the astronaut salivary microbiome and the search for a microbiome biomarker for viral reactivation

The cyclic nucleotide-gated channel CNGC14 regulates root gravitropism in Arabidopsis thaliana.

Telomere length assessments of muscle stem cells in rodent and human skeletal muscle sections

Persistent NF-κB activation in muscle stem cells induces proliferation-independent telomere shortening

Piezo1 regulates the regenerative capacity of skeletal muscles via orchestration of stem cell morphological states.

Impacts of radiation exposure, hindlimb unloading, and recovery on murine skeletal muscle cell telomere length.

Ethylene-induced flavonol accumulation in guard cells suppresses reactive oxygen species and modulates stomatal aperture

Transcriptional and Hormonal Regulation of Gravitropism of Woody Stems in Populus.

Endosidin2 targets conserved exocyst complex subunit EXO70 to inhibit exocytosis

A conditional mutation in SCD1 reveals linkage between PIN protein trafficking, auxin transport, gravitropism, and lateral root initiation.

A comprehensive SARS-CoV-2 and COVID-19 review, Part 1: Intracellular overdrive for SARS-CoV-2 infection.

Changes in nuclear shape and gene expression in response to simulated microgravity are LINC complex-dependent.

Growth of Carnobacterium spp. from permafrost under low pressure, temperature, and anoxic atmosphere has implications for Earth microbes on Mars

Complete Genome Sequence of Carnobacterium gilichinskyi Strain WN1359T (DSM 27470T)

Exposure of Bacillus subtilis to low pressure (5 kilopascals) induces several global regulons, including those involved in the SigB-mediated general stress response

Resistance of Bacillus subtilis Spore DNA to Lethal Ionizing Radiation Damage Relies Primarily on Spore Core Components and DNA Repair, with Minor Effects of Oxygen Radical Detoxification

Cultivation of Staphylococcus epidermidis in the human spaceflight environment leads to alterations in the frequency and spectrum of spontaneous rifampicin-resistance mutations in the rpoB gene

Experimental Evolution of Bacillus subtilis

Cultivation in space flight produces minimal alterations in the susceptibility of Bacillus subtilis cells to 72 different antibiotics and growth-inhibiting compounds

Alterations in the Spectrum of Spontaneous Rifampicin-Resistance Mutations in the Bacillus subtilis rpoB Gene after Cultivation in the Human Spaceflight Environment

Mechanotransduction in Prokaryotes: A Possible Mechanism of Spaceflight Adaptation

Environmental dependence of competitive fitness in rifampin-resistant rpoB mutants of Bacillus subtilis.

Analysis of interactions of Salmonella type three secretion mutants with 3-D intestinal epithelial cells.

Organotypic 3D cell culture models: using the rotating wall vessel to study host-pathogen interactions.

Induction of attachment-independent biofilm formation and repression of Hfq expression by low-fluid-shear culture of Staphylococcus aureus

Characterization of the Salmonella enterica serovar Typhimurium ydcI gene which encodes a conserved DNA binding protein required for full acid stress resistance.

Evaluation of microorganisms cultured from injured and repressed tissue regeneration sites in endangered giant aquatic Ozark Hellbender salamanders.

Transcriptional and proteomic responses of Pseudomonas aeruginosa PAO1 to spaceflight conditions involve Hfq regulation and reveal a role for oxygen.

New insights into the bacterial fitness-associated mechanisms revealed by the characterization of large plasmids of an avian pathogenic E. coli

Lack of norovirus replication and histo-blood group antigen expression in 3-dimensional intestinal epithelial cells

Conservation of the low-shear modeled microgravity response in Enterobacteriaceae and analysis of the trp genes in this response.

Mimicking the host and its microenvironment in vitro for studying mucosal infections by Pseudomonas aeruginosa.

Effects of Sex and Gender on Adaptation to Space: Immune System

Recellularization of decellularized lung scaffolds is enhanced by dynamic suspension culture.

Three-dimensional organotypic co-culture model of intestinal epithelial cells and macrophages to study Salmonella enterica colonization patterns.

Modeling Host-Pathogen Interactions in the Context of the Microenvironment: 3-D Cell Culture Comes of Age.

Evaluating the effect of spaceflight on the host–pathogen interaction between human intestinal epithelial cells and Salmonella Typhimurium

Rapid phenotypic response of LSMMG-'primed' Candida albicans.

Spaceflight enhances cell aggregation and random budding in Candida albicans.

Growth and antifungal resistance of the pathogenic yeast, Candida albicans, in the microgravity environment of the International Space Station: An aggregate of multiple flight experiences.

Challenges and considerations for single-cell and spatially resolved transcriptomics sample collection during spaceflight.

Direct RNA sequencing of astronaut blood reveals spaceflight-associated m6A increases and hematopoietic transcriptional responses

Collection of biospecimens from the inspiration4 mission establishes the standards for the space omics and medical atlas (SOMA)

Microfluidics-enabled method to identify modes of Caenorhabditis elegans paralysis in four anthelmintics.

Multiparameter behavioral analyses provide insights to mechanisms of cyanide resistance in Caenorhabditis elegans.

Growth performance and root transcriptome remodeling of Arabidopsis in response to Mars-like levels of magnesium sulfate.

The 14-3-3 proteins of Arabidopsis regulate root growth and chloroplast development as components of the photosensory system.

14-3-3 phosphoprotein interaction networks - does isoform diversity present functional interaction specification?

Plant growth strategies are remodeled by spaceflight

Spaceflight transcriptomes: unique responses to a novel environment.

Fundamental plant biology enabled by the space shuttle.

Organ-specific remodeling of the Arabidopsis transcriptome in response to spaceflight.

A method for preparing spaceflight RNAlater-fixed Arabidopsis thaliana (Brassicaceae) tissue for scanning electron microscopy.

ARG1 Functions in the Physiological Adaptation of Undifferentiated Plant Cells to Spaceflight

A Member of the CONSTANS-Like Protein Family is a Putative Regulator of ROS Homeostasis and Spaceflight Physiological Adaptation

HSFA2 Functions in the Physiological Adaptation of Undifferentiated Plant Cells to Spaceflight.

Neutrophil to Lymphocyte ratio: A biomarker to monitor the immune status of astronauts.

Beyond low-Earth orbit: Characterizing immune and microRNA differentials following simulated deep spaceflight conditions in mice.

Immunological and hematological outcomes following protracted low dose/low dose rate ionizing radiation and simulated microgravity

Epigenomic regulators elongator complex subunit 2 and methyltransferase 1 differentially condition the spaceflight response in Arabidopsis

Plants grown in Apollo lunar regolith present stress-associated transcriptomes that inform prospects for lunar exploration

Artificial gravity partially protects space-induced neurological deficits in Drosophila melanogaster.

Utilizing the KSC fixation tube to conduct human-tended plant biology experiments on a suborbital spaceflight

Changes in Mouse Thymus and Spleen after Return from the STS-135 Mission in Space

Post-Spaceflight (STS-135) Mouse Splenocytes Demonstrate Altered Activation Properties and Surface Molecule Expression.

Changes in the distribution and function of leukocytes after whole-body iron ion irradiation.

Is spaceflight-induced immune dysfunction linked to systemic changes in metabolism?

Spaceflight Activates Autophagy Programs and the Proteasome in Mouse Liver

Vive la radiorésistance!: Converging research in radiobiology and biogerontology to enhance human radioresistance for deep space exploration and colonization.

Proteomic analysis of mouse brain subjected to spaceflight.

Transcriptomic effects on the mouse heart following 30 days on the International Space Station.

Spaceflight-induced gene expression profiles in the mouse brain are attenuated by treatment with the antioxidant BuOE

Basal signaling regulates plant growth and development

Phosphoinositide-signaling is one component of a robust plant defense response

Uncovering transcriptional responses to fractional gravity in Arabidopsis roots

Conserved plant transcriptional responses to microgravity from two consecutive spaceflight experiments.

RNAseq analysis of rodent spaceflight experiments is confounded by sample collection techniques

Functional changes in the snail statocyst system elicited by microgravity

Simulated microgravity impairs human NK [natural killer] cell cytotoxic activity against space radiation-relevant leukemic cells

Multi-analyte biochip (MAB) based on all-solid-state ion-selective electrodes (ASSISE) for physiological research

Lab-on-a-chip approaches for space-biology research.

Plant chemical genomics: gravity sensing and response.

The interaction of vortical flows with red cells in venous valve mimics.

Mammalian and Invertebrate Models as Complementary Tools for Gaining Mechanistic Insight on Muscle Responses to Spaceflight

Investigation of simulated microgravity effects on Streptococcus mutans physiology and global gene expression.

Altered quorum sensing and physiology of Staphylococcus aureus during spaceflight detected by multi-omics data analysis

Homotypic vacuole fusion requires VTI11 and is regulated by phosphoinositides

REGULATOR OF BULB BIOGENESIS1 (RBB1) Is Involved in Vacuole Bulb Formation in Arabidopsis.

Phosphoinositides control the localization of HOPS subunit VPS41, which together with VPS33 mediates vacuole fusion in plants.

Microgravity enhances the phenotype of Arabidopsis zigzag-1 and reduces the Wortmannin-induced vacuole fusion in root cells.

Hypergravity disruption of homeorhetic adaptations to lactation in rat dams include changes in circadian clocks

Intrauterine exposure to maternal stress alters Bdnf IV DNA methylation and telomere length in the brain of adult rat offspring.

Influence of gonadectomy on muscle health in micro- and partial-gravity environments in rats.

Sex differences in muscle health in simulated micro- and partial-gravity environments in rats.

Brassinazole resistant 1 (BZR1)-dependent brassinosteroid signalling pathway leads to ectopic activation of quiescent cell division and suppresses columella stem cell differentiation

Proteomic study of microsomal proteins reveals a key role for Arabidopsis Annexin 1 in mediating heat stress-induced increase in intracellular calcium levels.

Apyrase inhibitors enhance the ability of diverse fungicides to inhibit the growth of different plant-pathogenic fungi

ANN1 and ANN2 Function in Post-Phloem Sugar Transport in Root Tips to Affect Primary Root Growth

Mitochondria-targeted human catalase in the mouse longevity MCAT model mitigates head-tilt bedrest-induced neuro-inflammation in the hippocampus.

Structural and functional properties of bone are compromised in amyotrophic lateral sclerosis mice.

Longitudinal time course of muscle impairments during partial weight-bearing in rats

The partial weight-bearing rat model using a pelvic harness does not impact stress or hindlimb blood flow.

Dose-dependent skeletal deficits due to varied reductions in mechanical loading in rats.

Approaching Gravity as a Continuum Using the Rat Partial Weight-Bearing Model

Hindlimb suspension in Wistar rats: Sex-based differences in muscle response

Adaptation to full weight-bearing following disuse in rats: The impact of biological sex on musculoskeletal recovery

Effects of liquid cultivation on gene expression and phenotype of C. elegans.

Transcriptomic Signature of the Simulated Microgravity Response in Caenorhabditis elegans and Comparison to Spaceflight Experiments.

Enabling clonal analyses of yeast in outer space by encapsulation and desiccation in hollow microparticles.

Caenorhabditis elegans in microgravity: An omics perspective

Dried plum diet protects from bone loss caused by ionizing radiation

Dietary countermeasure mitigates simulated spaceflight-induced osteopenia in mice

Simulated microgravity alters gene regulation linked to immunity and cardiovascular disease

Autophagy and its consequences for platelet biology

A new role of NAP1L1 in megakaryocytes and human platelets

Evaluation of rodent spaceflight in the NASA animal enclosure module for an extended operational period (up to 35 days)

Morphology of Penicillium rubens Biofilms Formed in Space

Explainable machine learning identifies multi-omics signatures of muscle response to spaceflight in mice

Microbial adaptation to spaceflight is correlated with bacteriophage-encoded functions

Influence of the spaceflight environment on macrophage lineages

MARSBOx: Fungal and bacterial endurance from a balloon-flown analog mission in the stratosphere

In situ linkage of fungal and bacterial proliferation to microbiologically influenced corrosion in B20 biodiesel storage tanks.

Identification of metagenome-assembled genomes containing antimicrobial resistance genes, isolated from an advanced water treatment facility.

Nature of pre-earthquake phenomena and their effects on living organisms

The rapid diagnosis and effective inhibition of coronavirus using spike antibody attached gold nanoparticles

Blocking SARS-CoV-2 Delta variant (B.1.617.2) spike protein receptor-binding domain binding with the ACE2 receptor of the host cell and inhibiting virus infections using human host defense peptide-conjugated graphene quantum dots.

Safety and pharmacokinetics of intranasally administered heparin

Inhibition of SARS-CoV-2 wild-type (Wuhan-Hu-1) and Delta (B.1.617.2) strains by marine sulfated glycans.

Inhibition of Cytomegalovirus by Pentacta pygmaea Fucosylated Chondroitin Sulfate Depends on Its Molecular Weight

A Tissue Retrieval and Postharvest Processing Regimen for Rodent Reproductive Tissues Compatible with Long-Term Storage on the International Space Station and Postflight Biospecimen Sharing Program

Effects of sex and gender on adaptations to space: reproductive health

Effects of spaceflight on the muscles of the murine shoulder.

Multiscale effects of spaceflight on murine tendon and bone

Reproducible changes in the gut microbiome suggest a shift in microbial and host metabolism during spaceflight.

Failure to Generate Bone Marrow Adipocytes Does Not Protect Mice from Ovariectomy-Induced Osteopenia

Acute exposure to high dose gamma-radiation results in transient activation of bone lining cells

Morbid obesity attenuates the skeletal abnormalities associated with leptin deficiency in mice

Hypothalamic leptin gene therapy reduces body weight without accelerating age-related bone loss

Hypothalamic Leptin Gene Therapy Reduces Bone Marrow Adiposity in ob/ob Mice Fed Regular and High-Fat Diets.

Room temperature housing results in premature cancellous bone loss in growing female mice: implications for the mouse as a preclinical model for age-related bone loss.

Spaceflight-induced vertebral bone loss in ovariectomized rats is associated with increased bone marrow adiposity and no change in bone formation

Role of oestrogen receptor signaling in skeletal response to leptin in female ob/ob mice.

Effects of hypothalamic leptin gene therapy on osteopetrosis in leptin-deficient mice.

Leptin stimulates bone formation in ob/ob mice at doses having minimal impact on energy metabolism.

Bone Marrow Adipose Tissue Deficiency Increases Disuse-Induced Bone Loss in Male Mice